Shp1 binds Jak2 in the receptor complex

Stable Identifier
R-MMU-1169250
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Shp1 binds Jak2 in the receptor complex

SHP1 binds GH-activated JAK2 and controls the duration of GH-dependent JAK2 phosphorylation in the liver, consequently hepatic GH signaling is prolonged in mice lacking SHP1 (Hackett et al. 1999).

Literature References
PubMed ID Title Journal Year
9111009 Mapping of a cytoplasmic domain of the human growth hormone receptor that regulates rates of inactivation of Jak2 and Stat proteins

Sweitzer, S, Feldman, G, Wang, YD, Larner, AC, Wood, WI, Hackett, RH

J Biol Chem 1997
Participants
Orthologous Events
Reviewed
Created
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