Reactome | phospho-Nfkbib [cytosol]

phospho-Nfkbib [cytosol]

Stable Identifier

R-MMU-1168571

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-S19,S23-Ub-NFKBIB, Q60778

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Signaling by the B Cell Receptor (BCR) (Mus musculus)
    - Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
      - Activation of NF-kappaB in B cells (Mus musculus)
        
        SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)
        
        NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Mus musculus)
        
        NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Mus musculus)
        
        ub-p-IKB alpha,beta,epsilon [cytosol] (Mus musculus)
        
        phospho-Nfkbib [cytosol] (Mus musculus)
        
        NF-kappaB p50:p65:ub-p-IKB [cytosol] (Mus musculus)
        
        ub-p-IKB alpha,beta,epsilon [cytosol] (Mus musculus)
        
        phospho-Nfkbib [cytosol] (Mus musculus)
        
        Ubiquitinated IkB is degraded (Mus musculus)
        
        NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Mus musculus)
        
        NF-kappaB p50:c-Rel:ub-p-IKB [cytosol] (Mus musculus)
        
        ub-p-IKB alpha,beta,epsilon [cytosol] (Mus musculus)
        
        phospho-Nfkbib [cytosol] (Mus musculus)
        
        NF-kappaB p50:p65:ub-p-IKB [cytosol] (Mus musculus)
        
        ub-p-IKB alpha,beta,epsilon [cytosol] (Mus musculus)
        
        phospho-Nfkbib [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q60778

Gene Names

Nfkbib

Reference Genes

BioGPS Gene:18036 Nfkbib

ENSEMBL:ENSMUSG00000030595

KEGG Gene (Mus musculus):18036 Nfkbib

Monarch:18036 Nfkbib

NCBI Gene:18036 Nfkbib

UCSC:Q60778 Nfkbib

Reference Transcript

Other Identifiers

10561516

1421266_s_at

1446718_at

17488544

18036

4630133

4744155

4888277

4999618

5211726

5213807

5222231

5260741

5262945

5281694

5399408

5406141

5568788

5604080

99982_at

A_51_P259459

A_55_P1989733

A_55_P2051666

A_66_P120882

GE35802

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0007253

GO:0008150

GO:0009058

GO:0034641

GO:0043226

GO:0071222

ILMN_1257446

ILMN_2612007

U19799_s_at

mMC008604

Participant Of

hasMember

ub-p-IKB alpha,beta,epsilon [cytosol]

Other forms of this molecule

phospho-Nfkbib [cytosol]

Nfkbib [cytosol]

Inferred From

p-S19,S23-Ub-NFKBIB [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 19 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 23 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_035038.2, NP_001293151.1

Ensembl

ENSMUSP00000032815, ENSMUST00000085851, ENSMUST00000032815, ENSMUSP00000083012, ENSMUSG00000030595

PRO

Q60778

MGI

104752

PDB

1OY3, 1K3Z

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04207	6	Rela [nucleoplasm] (R-MMU-177676) Rela [cytosol] (R-MMU-168172) phospho-Rela [nucleoplasm] (R-MMU-5624468) phospho-Rela [nucleoplasm] (R-MMU-5660642) Rela [nucleoplasm] (R-MMU-8865233) Rela [nucleoplasm] (R-MMU-4755466)	0.693	12