Reactome | CDK4 [nucleoplasm]

CDK4 [nucleoplasm]

Stable Identifier

R-MMU-113843

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P30285

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30285 Cdk4

Gene Names

Cdk4, Crk3

Chain

initiator methionine:, chain:2-303

Reference Genes

BioGPS Gene:12567 Cdk4

KEGG:mmu:12567 Cdk4

Monarch:12567 Cdk4

NCBI Gene:12567 Cdk4

UCSC:P30285 Cdk4

Reference Transcript

RefSeq:NM_009870.3 Cdk4

Other Identifiers

101017_at

10366814

12567

1422439_a_at

1422440_at

1422441_x_at

160538_at

17237899

4347368

4468442

4529929

4543357

4550608

4590895

4652832

4695743

4705948

4794463

4846719

4944071

5075685

5315974

5472761

5565140

5616409

A_55_P1998188

A_55_P2163143

A_55_P2166639

GE35199

GO:0000082

GO:0000307

GO:0000785

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0005737

GO:0005829

GO:0005923

GO:0006468

GO:0007165

GO:0008284

GO:0009410

GO:0010288

GO:0010389

GO:0010468

GO:0010971

GO:0016020

GO:0016301

GO:0016740

GO:0030332

GO:0031965

GO:0033574

GO:0043065

GO:0043226

GO:0044877

GO:0045727

GO:0045793

GO:0048146

GO:0048471

GO:0050679

GO:0051301

GO:0051726

GO:0061469

GO:0071222

GO:0071353

GO:0097128

GO:0097129

GO:0097130

GO:0106310

GO:0140096

GO:1904628

GO:1904637

ILMN_2646203

ILMN_2690976

L01640_s_at

Msa.23042.0_s_at

Msa.6128.0_s_at

mMC015649

Participates

as an input of

CEBPA binds CDK4 (Mus musculus)

as a component of

as a member of

CDK4,CDK6 [nucleoplasm] (Mus musculus)

Other forms of this molecule

CDK4 [nucleoplasm]

phospho-Cdk4(Thr 286) [nucleoplasm]

Cdk4 [nucleoplasm]

CDK4 [cytosol]

phospho-p-T172-CDK4 [nucleoplasm]

Inferred From

CDK4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034000.1

ENSEMBL

ENSMUSP00000006911, ENSMUST00000006911

IntEnz

2.7.11.22

PRO

P30285

GlyGen

P30285

MGI

88357

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25322 Ccnd1	4	phospho-Ccnd1 [nucleoplasm] (R-MMU-75811) phospho-Ccnd1 [cytosol] (R-MMU-75813) Ccnd1 [cytosol] (R-MMU-182561) Ccnd1 [nucleoplasm] (R-MMU-182569)	0.944	15
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.623	2
UniProt:P46414 Cdkn1b	9	phospho-Cdkn1b [cytosol] (R-MMU-9632829) phospho-Cdkn1b [nucleoplasm] (R-MMU-9632832) Cdkn1b [cytosol] (R-MMU-5671974) phospho-Cdkn1b [cytosol] (R-MMU-198629) Cdkn1b [cytosol] (R-MMU-198622) phospho-Cdkn1b [cytosol] (R-MMU-8848438) phospho-Cdkn1b [nucleoplasm] (R-MMU-8942808) Cdkn1b [nucleoplasm] (R-MMU-182563) phospho-Cdkn1b [nucleoplasm] (R-MMU-187525)	0.564	2
UniProt:P30280	2	Ccnd2 [cytosol] (R-MMU-68340) Ccnd2 [nucleoplasm] (R-MMU-113827)	0.527	2
UniProt:P30282	2	Ccnd3 [cytosol] (R-MMU-68333) Ccnd3 [nucleoplasm] (R-MMU-113835)	0.527	2
UniProt:Q8CIG8	3	phospho-p-Y297,304,307-PRMT5 [nucleoplasm] (R-MMU-5211300) PRMT5 [nucleoplasm] (R-MMU-5205609) PRMT5 [cytosol] (R-MMU-191876)	0.499	3