SH2B proteins bind JAK2

Stable Identifier
R-HSA-997237
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The SH2B family has 3 members sharing a common domain structure, including a dimerization domain, a pleckstrin homology (PH) region, and a SH2 domain. The SH2 domain binds phosphotyrosines of various signal-transducing proteins such as c-Kit, MPL, EpoR. All are able to bind JAK2 phosphorylated at Tyr-813 (Bersenev et al. 2008, Kurzer et al. 2004, 2006), inhibiting JAK2 proliferative signaling (Gery et al. 2009).

Literature References
PubMed ID Title Journal Year
19293402 Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

Gery, S, Cao, Q, Gueller, S, Xing, H, Tefferi, A, Koeffler, HP

J Leukoc Biol 2009
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