Reactome | HP1 alpha binds Histone H3K9(me)3

HP1 alpha binds Histone H3K9(me)3

Stable Identifier

R-HSA-994106

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chromobox (CBX) genes encode members of the Heterochromatin Protein (HP) family. HP1 was discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals. Most animal species have several HP1 isoforms; humans have HP alpha, beta and gamme encoded by the genes CBX5, CBX1 and CBX3 respectively.
The HP1 amino-terminal chromodomain binds methylated lysine-9 of histone H3, causing transcriptional repression (Lachner et al. 2001). A crystal structure of human HP1 alpha in complex with H3K9(me)3 peptide is available (Amaya et al. 2008). The highly-conserved carboxy-terminal chromoshadow domain enables dimerization and also serves as a docking site for proteins involved in a wide variety of nuclear functions, from transcription to nuclear architecture.

Literature References

PubMed ID	Title	Journal	Year
11242053	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins Rea, S, O'Carroll, D, Mechtler, K, Lachner, M, Jenuwein, T	Nature	2001
	Human chromobox homolog 5 (CBX5) in complex with H3K9(me)3 peptide Bountra, C, Ouyang, H, Weigelt, J, Kozieradzki, I, Bochkarev, A, Arrowsmith, CH, Min, J, Edwards, AM, Amaya, MF, Ravichandran, M, Loppnau, P