Expression of Interferon-alpha and beta

Stable Identifier
R-HSA-994034
Type
Reaction [omitted]
Species
Homo sapiens
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The Interferon alpha and beta genes are transcribed and translated yielding IFNA and IFNB which are secreted. This process is positively regulated by Interferon Regulatory Factor 1 and negatively regulated by Interferon Regulatory Factor 2, which compete for binding to the same regulatory element (Harada et al. 1989).

Literature References
PubMed ID Title Journal Year
20627800 Regulation of immune cell homeostasis by type I interferons

Mattei, F, Schiavoni, G, Tough, DF

Cytokine Growth Factor Rev 2010
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