TRAMP:RNA exosome hydrolyzes oligoadenylated pre-rRNA 5' external transcribed spacer (5'ETS)

Stable Identifier
R-HSA-9935824
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleolus
ReviewStatus
5/5
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TRAMP:RNA exosome hydrolyzes oligoadenylated pre-rRNA 5' external transcribed spacer (5'ETS)
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After oligoadenylation by the TRAMP complex, the oligoadenylated 5' external transcribed sequence (5'ETS) cleaved from the 47S pre-rRNA is 3'-5' exonucleolytically hydrolyzed by the RNA exosome, which is bound to the TRAMP complex (Lubas et al. 2011, Sudo et al. 2016).
Literature References
PubMed ID Title Journal Year
21855801 Interaction profiling identifies the human nuclear exosome targeting complex

Lubas, M, Christensen, MS, Kristiansen, MS, Domanski, M, Falkenby, LG, Lykke-Andersen, S, Andersen, JS, Dziembowski, A, Jensen, TH

Mol. Cell 2011
27434818 Interaction properties of human TRAMP-like proteins and their role in pre-rRNA 5'ETS turnover

Sudo, H, Nozaki, A, Uno, H, Ishida, Y, Nagahama, M

FEBS Lett 2016
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Catalyst Activity

3'-5'-RNA exonuclease activity of TRAMP:RNA exosome [nucleolus]

Physical Entity
TRAMP:RNA exosome [nucleolus] (Homo sapiens)
Activity
3'-5'-RNA exonuclease activity (GO:0000175)
Authored
May, B  (2025-01-17)
Reviewed
Tong, L  (2025-10-23)
Created
May, B  (2025-01-18)
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