XRN2 5'-3' exonucleolytically hydrolyzes uncapped RNA

Stable Identifier
R-HSA-9935299
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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XRN2 5'-3' exonucleolytically hydrolyzes uncapped RNA
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XRN2 exonucleolytically cleaves 5' monophosphorylated RNAs (inferred from the yeast homolog Rat1 in Stevens and Poole 1995, reviewed in Aygun and Miki 2021) such as decapped RNAs (Brannan et al. 2012) and the 3' RNA products of cleavage during transcription termination by autocatalytic self-cleavage (West et al. 2004) and by the cleavage and polyadenylation (CPA) complex (Kaneko et al. 2007) and by the rixosome (Zhou et al. 2022). XRN2 also degrades intergenic transcripts that remain bound to chromatin (Agostini et al 2021).
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5'-3' RNA exonuclease activity of XRN2 [nucleoplasm]

Physical Entity
XRN2 [nucleoplasm] (Homo sapiens)
Activity
5'-3' RNA exonuclease activity (GO:0004534)
Inferred From
Rat1 (Xrn2) exonucleolytically degrades uncapped RNA (Saccharomyces cerevisiae)
Authored
May, B  (2025-01-12)
Reviewed
Tong, L  (2025-10-23)
Created
May, B  (2025-01-14)
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