Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2

Stable Identifier
R-HSA-9934887
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The proteasome degrades K48-polyubiquitinylated CRY1 and CRY2 in the cytosol (inferred from mouse homologs). An SCF E3 ligase complex containing FBXL21 causes slow degradation of CRY proteins in the cytosol, but inhibits FBXL3-dependent degradation of CRY proteins in the nucleus (Hirano et al. 2013, and inferred from mouse homologs).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Proteolysis of K48polyUb-K107,p-S-Cry1,K48polyUb-K125,p-S-Cry2 (Mus musculus)
Authored
May, B  (2025-01-11)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2025-01-12)
Cite Us!