Reactome | SMARCC1 and SMARCC2 bind SMARCD1

SMARCC1 and SMARCC2 bind SMARCD1

Stable Identifier

R-HSA-9934027

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Unlike mouse esBAF, which appears to only contain BAF155 (equivalent to human SMARCC1), human esBAF contains a dimer of BAF155 (SMARCC1) and BAF170 (SMARCC2) (Ho, Ronan et al, 2009, Ho, Jothi et al, 2009; Wade et al, 2015; Zhang et al, 2014). The SMARCC dimer interacts with SMARCD1 (BAF60A) to form the core assembly module; SMARCD2/BAF60B and SMARCD3/BAF60C have been variably reported in different esBAF complex purifications (Ho, Ronan et al, 2009, Ho, Jothi et al, 2009; Zhang et al, 2014; reviewed in Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Innis and Cabot, 2020).

Literature References

PubMed ID	Title	Journal	Year
26119756	MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs Wade, SL, Langer, LF, Ward, JM, Archer, TK	Stem Cells	2015
25241744	Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells Zhang, X, Li, B, Li, W, Ma, L, Zheng, D, Li, L, Yang, W, Chu, M, Chen, W, Mailman, RB, Zhu, J, Fan, G, Archer, TK, Wang, Y	Stem Cell Reports	2014
32958894	COMPASS and SWI/SNF complexes in development and disease Cenik, BK, Shilatifard, A	Nat Rev Genet	2021
19279218	An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network Ho, L, Jothi, R, Ronan, JL, Cui, K, Zhao, K, Crabtree, GR	Proc Natl Acad Sci U S A	2009
26601204	Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics Kadoch, C, Crabtree, GR	Sci Adv	2015
33143733	GBAF, a small BAF sub-complex with big implications: a systematic review Innis, SM, Cabot, B	Epigenetics Chromatin	2020
19279220	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency Ho, L, Ronan, JL, Wu, J, Staahl, BT, Chen, L, Kuo, A, Lessard, J, Nesvizhskii, AI, Ranish, J, Crabtree, GR	Proc Natl Acad Sci U S A	2009