Reactome | Formation of the polybromo-BAF (pBAF) complex

Formation of the polybromo-BAF (pBAF) complex

Stable Identifier

R-HSA-9933939

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Formation of the polybromo-BAF (pBAF) complex

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Mammalian pBAF (polybromo-associated BAF) complex is paralogous to the RSC (remodel the structure of chromatin) complex of S. cerevisiae (Xue et al, 2000; reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Wang and Tang, 2023). Mammalian pBAF shares many of the same core subunits as cBAF, but is distinguished by the presence of ARID2 in place of ARID1A or B (Wang, Cote et al, 1996; Wang, Xue et al, 1996; Xue et al, 2000; Lemon et al, 2001; Yan et al, 2005; Mashtalir et al, 2018; Mashtalir et al, 2020; de Castro 2017; Wang et al, 2022; Yuan et al, 2022; Feoktistov et al, 2023). pBAF also contains unique subunits PHF10, BRD7 and PBRM (Kaeser et al, 2008; Mashtalir et al, 2018; Mashtalir et al, 2020; Wang et al, 2022; Yuan et al, 2022; reviewed in Mittal and Roberts, 2020; Cenik and Shilatifard, 2021; Innis and Cabot, 2020).

Literature References

PubMed ID	Title	Journal	Year
37031881	SWI/SNF complexes and cancers Wang, L, Tang, J	Gene	2023
38066320	Chromatin Remodeling Complex PBAF Activates and Represses Inflammatory Genes Feoktistov, AV, Georgieva, SG, Soshnikova, NV	Dokl Biochem Biophys	2023
32303701	The SWI/SNF complex in cancer - biology, biomarkers and therapy Mittal, P, Roberts, CWM	Nat Rev Clin Oncol	2020
33053319	A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms Mashtalir, N, Suzuki, H, Farrell, DP, Sankar, A, Luo, J, Filipovski, M, D'Avino, AR, St Pierre, R, Valencia, AM, Onikubo, T, Roeder, RG, Han, Y, He, Y, Ranish, JA, Dimaio, F, Walz, T, Kadoch, C	Cell	2020
11780067	Selectivity of chromatin-remodelling cofactors for ligand-activated transcription Lemon, B, Inouye, C, King, DS, Tjian, R	Nature	2001
8895581	Purification and biochemical heterogeneity of the mammalian SWI-SNF complex Wang, W, Côté, J, Xue, Y, Zhou, S, Khavari, PA, Biggar, SR, Muchardt, C, Kalpana, GV, Goff, SP, Yaniv, M, Workman, JL, Crabtree, GR	EMBO J.	1996
32958894	COMPASS and SWI/SNF complexes in development and disease Cenik, BK, Shilatifard, A	Nat Rev Genet	2021
35477757	Structure of human chromatin-remodelling PBAF complex bound to a nucleosome Yuan, J, Chen, K, Zhang, W, Chen, Z	Nature	2022
11078522	The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes Xue, Y, Canman, JC, Lee, CS, Nie, Z, Yang, D, Moreno, GT, Young, MK, Salmon, ED, Wang, W	Proc Natl Acad Sci U S A	2000
33143733	GBAF, a small BAF sub-complex with big implications: a systematic review Innis, SM, Cabot, B	Epigenetics Chromatin	2020
18809673	BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells Kaeser, MD, Aslanian, A, Dong, MQ, Yates, JR, Emerson, BM	J Biol Chem	2008
8804307	Diversity and specialization of mammalian SWI/SNF complexes Wang, W, Xue, Y, Zhou, S, Kuo, A, Cairns, BR, Crabtree, GR	Genes Dev	1996
36496390	Structure of nucleosome-bound human PBAF complex Wang, L, Yu, J, Yu, Z, Wang, Q, Li, W, Ren, Y, Chen, Z, He, S, Xu, Y	Nat Commun	2022
28381560	The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes de Castro, RO, Previato, L, Goitea, V, Felberg, A, Guiraldelli, MF, Filiberti, A, Pezza, RJ	J Biol Chem	2017
30343899	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C	Cell	2018
15985610	PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes Yan, Z, Cui, K, Murray, DM, Ling, C, Xue, Y, Gerstein, A, Parsons, R, Zhao, K, Wang, W	Genes Dev	2005