Reactome | SMARCC binds SMARCD

SMARCC binds SMARCD

Stable Identifier

R-HSA-9932448

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SWI/SNF complex assembly begins by the binding of a dimer of SMARC subunits (SMARCC1 and SMARCC2, also known as BAF155 and BAF 170, respectively) to SMARCD1, 2 or 3 (also known as BAF60A, BAF60B or BAF60C, respectively) (Mashtalir et al, 2018; Mashtalir et al, 2020). SMARCC has been shown to form dimers in all possible combinations, with SMARCC1 homodimers common in human embryonic stem cells (ESCs) and SMARCC1:SMARCC2 heterodimers occurring in differentiated cell types (Ho et al, 2009; Wang et al, 1996). The SMARCC:SMARCD trimer was identified as the initiating core of SWI/SNF assembly on the basis of density sedimentation and cross-linking analysis of HEK293 nuclear extracts (Mashtalir et al, 2018; Mashtalir et al 2020), in contrast to earlier studies that suggested that complex assembly nucleates around a tetramer of SMARCC1, SMARCC2, SMARCA4 and SMARCB1 (Phelan et al, 1999).

Literature References

PubMed ID	Title	Journal	Year
10078207	Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits Phelan, ML, Sif, S, Narlikar, GJ, Kingston, RE	Mol. Cell	1999
33053319	A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms Mashtalir, N, Suzuki, H, Farrell, DP, Sankar, A, Luo, J, Filipovski, M, D'Avino, AR, St Pierre, R, Valencia, AM, Onikubo, T, Roeder, RG, Han, Y, He, Y, Ranish, JA, Dimaio, F, Walz, T, Kadoch, C	Cell	2020
8804307	Diversity and specialization of mammalian SWI/SNF complexes Wang, W, Xue, Y, Zhou, S, Kuo, A, Cairns, BR, Crabtree, GR	Genes Dev	1996
19279220	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency Ho, L, Ronan, JL, Wu, J, Staahl, BT, Chen, L, Kuo, A, Lessard, J, Nesvizhskii, AI, Ranish, J, Crabtree, GR	Proc Natl Acad Sci U S A	2009
30343899	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C	Cell	2018