Reactome | OSTC [endoplasmic reticulum membrane]

OSTC [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9932190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

DC2, fullName evidence="7"Oligosaccharyltransferase complex subunit OSTC, OSTC_HUMAN

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus Genome Translation and Replication (Homo sapiens)
        
        Maturation of DENV proteins (Homo sapiens)
        
        E is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)
        
        Pre-NS1 folds and is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)
        
        pre-M is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        CD274 N-linked glycosylation in ER (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transfer of N-glycan to the protein (Homo sapiens)
      - OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        OSTC [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRP0 OSTC

Gene Names

OSTC, DC2, HDCMD45P, HSPC307

Chain

chain:1-149

Reference Genes

BioGPS Gene:58505 OSTC

COSMIC (genes):OSTC OSTC

CTD Gene:58505 OSTC

dbSNP Gene:58505 OSTC

ENSEMBL:ENSG00000198856 OSTC

HGNC:24448 OSTC

KEGG:hsa:58505 OSTC

Monarch:58505 OSTC

NCBI Gene:58505 OSTC

OMIM:619023 OSTC

UCSC:Q9NRP0 OSTC

Reference Transcript

Other Identifiers

11721565_x_at

11756429_x_at

16969639

16969646

223001_3p_at

223001_PM_at

223001_at

2738950

2738951

2738952

2738953

2738954

2738956

2738957

2738963

2738964

2738967

2740062

2981977

2981980

3000924

3452071

55774_at

58505

8096771

8096777

A_14_P121560

A_23_P411814

GE54609

GO:0004579

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0016740

GO:0018279

GO:0030674

GO:0043686

GO:0060090

GO:0160226

HMNXSV003053920

ILMN_1776005

ILMN_2056167

PH_hs_0029065

PH_hs_0035513

TC04000559.hg

TC04000560.hg

g9295177_3p_s_at

Participates

as a component of

OST-A Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Homologues of OSTC [endoplasmic reticulum membrane] (Canis familiaris)

LOC100684247 [endoplasmic reticulum membrane] (Canis familiaris)

OSTC [endoplasmic reticulum membrane] (Bos taurus)

OSTC [endoplasmic reticulum membrane] (Canis familiaris)

OSTC [endoplasmic reticulum membrane] (Sus scrofa)

ostc [endoplasmic reticulum membrane] (Danio rerio)

ostc [endoplasmic reticulum membrane] (Xenopus tropicalis)

Ostc [endoplasmic reticulum membrane] (Mus musculus)

Ostc [endoplasmic reticulum membrane] (Rattus norvegicus)

Ghost homologue of OSTC [endoplasmic reticulum membrane] (Gallus gallus)

Cross References

RefSeq

NP_001254747.1, NP_001254746.1, NP_067050.1

ENSEMBL

ENSP00000354676, ENSP00000426167, ENST00000512478, ENSG00000198856, ENST00000361564

OpenTargets

ENSG00000198856

GeneCards

OSTC

HPA

ENSG00000198856-OSTC

PRO

Q9NRP0

Pharos - Targets

Q9NRP0

GlyGen

Q9NRP0

PDB

8PN9, 8B6L, 6S7O

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.556	3
UniProt:P80370 DLK1	1	DLK1 [plasma membrane] (R-HSA-1604447)	0.527	2