Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of DBP

Stable Identifier
R-HSA-9929321
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of DBP
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Phosphorylated BMAL1:CLOCK binds E-boxes in the promoter of the DBP gene and activates transcription (inferred from mouse homologs). DBP protein then binds D-boxes in promoters of circadian genes such as PER1 and enhances transcription (inferred from mouse homologs). DBP is expressed in a circadian rhythm in the suprachiasmatic nucleus (inferred from mouse homologs). Levels of DBP mRNA are highest in the morning (inferred from mouse homologs).
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Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:DBP gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm]
Inferred From
Phosphorylated Bmal1:Clock positively regulates expression of Dbp (Mus musculus)
Authored
May, B  (2024-11-23)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-11-24)
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