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MFN1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-992745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-1, MFN1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q16611
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
MFN1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWA4 MFN1
Gene Names
MFN1
Chain
chain:1-741
Reference Genes
BioGPS Gene:55669 MFN1
COSMIC (genes):MFN1 MFN1
CTD Gene:55669 MFN1
dbSNP Gene:55669 MFN1
ENSEMBL:ENSG00000171109 MFN1
ENSEMBL_homo_sapiens_GENE:ENSG00000171109.19 MFN1
HGNC:18262 MFN1
KEGG Gene (Homo sapiens):55669 MFN1
Monarch:55669 MFN1
NCBI Gene:55669 MFN1
OMIM:608506 MFN1
UCSC:Q8IWA4 MFN1
Reference Transcript
RefSeq:XM_005247596.3 MFN1
RefSeq:NM_033540.2 MFN1
Other Identifiers
11731456_at
11731457_s_at
11755894_a_at
16948249
17125550
207098_PM_s_at
207098_s_at
211801_PM_x_at
211801_x_at
217043_PM_s_at
217043_s_at
2653933
2653934
2653937
2653938
2653940
2653941
2653942
2653944
2653945
2653946
2653947
2653948
2653949
2653952
2653955
2653957
2653959
2653961
2653962
2653963
2653964
2653969
2653970
2653971
2653972
2653973
2653974
2653978
2653980
2653982
38899_s_at
3986954
3986956
3986960
43500_at
55669
69284_at
8084045
A_14_P123996
A_23_P80648
GE63011
GO:0000166
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005739
GO:0005741
GO:0007005
GO:0008053
GO:0010918
GO:0016020
GO:0016787
GO:0042802
GO:0043226
GO:0046039
GO:0051646
GO:0055086
GO:0098799
GO:1901135
HMNXSV003009376
HMNXSV003048063
Hs.197877.3.A1_3p_a_at
ILMN_1664186
ILMN_1708959
PH_hs_0025289
TC03000953.hg
g12744895_3p_a_at
g8923620_3p_a_at
p12103
Participates
as a member of
RHOT2 effectors [cytosol] (Homo sapiens)
as a candidate of
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
as an input of
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
Other forms of this molecule
K48polyUb-MFN1 [mitochondrial outer membrane]
Inferred To
MFN1 [mitochondrial outer membrane]
(Bos taurus)
MFN1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
MFN1 [mitochondrial outer membrane]
(Canis familiaris)
MFN1 [mitochondrial outer membrane]
(Drosophila melanogaster)
MFN1 [mitochondrial outer membrane]
(Gallus gallus)
MFN1 [mitochondrial outer membrane]
(Mus musculus)
MFN1 [mitochondrial outer membrane]
(Plasmodium falciparum)
MFN1 [mitochondrial outer membrane]
(Rattus norvegicus)
MFN1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
MFN1 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
MFN1 [mitochondrial outer membrane]
(Sus scrofa)
mfn1 [mitochondrial outer membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005247653.2
,
NP_284941.2
Guide to Pharmacology - Targets
3130
OpenTargets
ENSG00000171109
GeneCards
Q8IWA4
HPA
ENSG00000171109-MFN1
Ensembl
ENST00000471841
,
ENSP00000349963
,
ENSP00000420617
,
ENSG00000171109
,
ENST00000357390
,
ENSP00000263969
,
ENST00000263969
PRO
Q8IWA4
Pharos - Targets
Q8IWA4
Orphanet
24700
HMDB Protein
HMDBP08481
PDB
5GNS
,
5GNU
,
5YEW
,
5GOF
,
5GO4
,
5GNR
,
5GOE
,
5GOM
,
5GNT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IWA4 MFN1
2
K48polyUb-MFN1 [mitochondrial outer membrane]
(R-HSA-5205679)
MFN1 [mitochondrial outer membrane]
(R-HSA-992745)
0.618
13
UniProt:O95140 MFN2
2
MFN2 [mitochondrial outer membrane]
(R-HSA-992714)
K48polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-5205668)
0.564
2
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.527
2
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