Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Dual-specific AKAPs bind type I and II PKA regulatory subunits
Stable Identifier
R-HSA-992708
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein kinase A (PKA) refers to a family of multimeric enzyme complexes whose activity is dependent on the level of cyclic AMP (cAMP), hence PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. PKA is a holoenzyme complex consisting of two regulatory and two catalytic subunits. When cAMP levela are low the holoenzyme remains intact and is inactive. When the concentration of cAMP rises (e.g. as a result of adenylate cyclase activation by G protein-coupled receptors coupled to Gs, or inhibition of phosphodiesterases that degrade cAMP) cAMP binds to two binding sites on the regulatory subunits, leading to the release and activation of the catalytic subunits. The regulatory subunits of PKA are also important for localizing the kinase inside the cell. A-kinase anchor proteins (AKAPs) bind to the regulatory subunits and to cytoskeletal structures or membranes, anchoring the enzyme complex to a particular subcellular compartment. Dual-specificity A kinase-anchoring proteins (AKAP1/D-AKAP1) and (AKAP10/D-AKAP2) interact with the type I and type II regulatory subunits of PKA (Huang et al. 1997). AKAP10 additionally has two regulator of G-protein signaling (RGS) domains, giving it the potential to coordinate a signaling complex that links cAMP signaling with G-protein-coupled receptor (GPCR) signaling (Burns-Hamuro et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
9326583
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
Taylor, SS
,
Weiner, JA
,
Chun, J
,
Durick, K
,
Huang, LJ
Proc Natl Acad Sci U S A
1997
9065479
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits
Taylor, SS
,
Weiner, JA
,
Chun, J
,
Durick, K
,
Huang, LJ
J Biol Chem
1997
Participants
Input
Dual-specific AKAPs [cytosol]
(Homo sapiens)
PKA tetramer [cytosol]
(Homo sapiens)
Output
Dual-specific AKAPs:PKA tetramer [cytosol]
(Homo sapiens)
Participates
as an event of
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Orthologous Events
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Canis familiaris)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Gallus gallus)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Schizosaccharomyces pombe)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Sus scrofa)
Dual-specific AKAPs bind type I and II PKA regulatory subunits (Xenopus tropicalis)
Authored
Akkerman, JW (2010-10-29)
Reviewed
Ouwehand, WH (2010-11-12)
Created
Jupe, S (2010-11-04)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text