MITF-M-dependent CDH1 gene expression

Stable Identifier
R-HSA-9926527
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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MITF-M-dependent CDH1 gene expression
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Expression of E-cadherin (CDH1) is upregulated in an MITF-M dependent manner during melanocyte lineage differentiation and in melanoma cells (Mansky et al, 2002; Dilshat et al, 2021; Laurette et al, 2015).
Changes in relative levels of E- and N-cadherin contribute to migration of neural crest cells during melanocyte differentiation, and also play a role during the development of melanoma (Li et al, 2001; Gupta et al, 2005; LaBonne et al, 2000; reviewed in Mort et al, 2015).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
16142232 The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

Gupta, PB, Kuperwasser, C, Brunet, JP, Ramaswamy, S, Kuo, WL, Gray, JW, Naber, SP, Weinberg, RA

Nat Genet 2005
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
11325858 N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells

Li, G, Satyamoorthy, K, Herlyn, M

Cancer Res 2001
10772801 Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration

LaBonne, C, Bronner-Fraser, M

Dev Biol 2000
25670789 The melanocyte lineage in development and disease

Mort, RL, Jackson, IJ, Patton, EE

Development 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:CDH1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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