MITF-M-dependent SOX2 gene expression

Stable Identifier
R-HSA-9926523
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent SOX2 gene expression
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Global expression and DNA binding analysis suggests that the SOX2 gene is a target of MITF-M-dependent repression in melanoma cells (Dilshat et al, 2021; Laurette et al, 2015). SOX2 is a transcriptional repressor that is present on the promoter of the MITF gene in neural crest cells prior to melanocyte fate specification. With FOXD3, SOX2 represses MITF expression and promotes instead the development of the Schwann cell precursor fate (Adameyko et al, 2012). Although the mechanisms for lifting SOX2-mediated repression in the melanocyte cell line are not known, once expressed, MITF itself represses further SOX2 expression (Adameyko et al, 2012; reviewed in Mort et al, 2015; Goding and Arnheiter, 2019). Although SOX2 is upregulated in many cancers, its role in tumor progression in melanoma is not entirely clear (Weina et al, 2016; Schaefer et al, 2017; reviewed in Novak et al, 2020)
Literature References
PubMed ID Title Journal Year
31412296 SOX2 in development and cancer biology

Novak, D, Hüser, L, Elton, JJ, Umansky, V, Altevogt, P, Utikal, J

Semin Cancer Biol 2020
28368416 Sox2 is dispensable for primary melanoma and metastasis formation

Schaefer, SM, Segalada, C, Cheng, PF, Bonalli, M, Parfejevs, V, Levesque, MP, Dummer, R, Nicolis, SK, Sommer, L

Oncogene 2017
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
27105574 TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells

Weina, K, Wu, H, Knappe, N, Orouji, E, Novak, D, Bernhardt, M, Hüser, L, Larribère, L, Umansky, V, Gebhardt, C, Utikal, J

Pigment Cell Melanoma Res 2016
22186729 Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest

Adameyko, I, Lallemend, F, Furlan, A, Zinin, N, Aranda, S, Kitambi, SS, Blanchart, A, Favaro, R, Nicolis, S, Lübke, M, Müller, T, Birchmeier, C, Suter, U, Zaitoun, I, Takahashi, Y, Ernfors, P

Development 2012
25670789 The melanocyte lineage in development and disease

Mort, RL, Jackson, IJ, Patton, EE

Development 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MITF-M dimer:SOX2 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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