MITF-M-dependent PXDN gene expression

Stable Identifier
R-HSA-9926520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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MITF-M-dependent PXDN gene expression
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PXDN (peroxidasin) is a heme-containing peroxidase that catalyzes the oxidation of bromide during the formation of collagen sulfilimine cross-links. Through its role in the assembly and stability of collagen fibers, PXDN contributes to the formation the formation and signaling of the extracellular matrix (Peterfi et al, 2009; Lee et al, 2020; reviewed in Cheng and Shi 2022). PXDN expression is repressed in melanoma cells in a manner that depends on MITF-M (Dilshat et al, 2021).
Literature References
PubMed ID Title Journal Year
35219848 Mammalian peroxidasin (PXDN): From physiology to pathology

Cheng, G, Shi, R

Free Radic Biol Med 2022
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
19590037 Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney

Péterfi, Z, Donkó, A, Orient, A, Sum, A, Prókai, A, Molnár, B, Veréb, Z, Rajnavölgyi, E, Kovács, KJ, Müller, V, Szabó, AJ, Geiszt, M

Am J Pathol 2009
32543734 Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly

Lee, SW, Kim, HK, Naidansuren, P, Ham, KA, Choi, HS, Ahn, HY, Kim, M, Kang, DH, Kang, SW, Joe, YA

FASEB J 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MITF-M dimer:PXDN gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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