MITF-M-dependent EDIL3 gene expression

Stable Identifier
R-HSA-9926519
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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EDIL3 encodes a 52 kDa secreted protein that binds to integrins, glycosaminoglycans and phosphatidylserine through its EGF domains and discoidin-1 like domains, respectively (reviewed in Li et al, 2021; Jiang et al, 2024). EDIL3 has roles in inflammation, cell adhesion and invasion and has been identified as a target of MITF-M-mediated repression in melanoma cells (Dilshat et al, 2021; Webster et al, 2014; Laurette et al, 2015).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
39206385 Developmental endothelial locus 1: the present and future of an endogenous factor in vessels

Jiang, D, Yue, H, Liang, WT, Wu, Z

Front Physiol 2024
34217213 Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

Li, M, Zhong, D, Li, G

Cell Mol Biol Lett 2021
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