MITF-M binds CDH1 gene

Stable Identifier
R-HSA-9926495
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MITF-M binds CDH1 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MITF-M binds to promoter and intronic elements of the E-cadherin (CDH1) to upregulate its expression as assessed by electrophoretic mobility shift and reporter gene assay, ChIP-seq and CUT-and-RUN DNA binding assay (Mansky et al, 2002; Dilshat et al, 2021; Laurette et al, 2015). Consistent with this, protein and mRNA levels of CDH1 are upregulated in melanoma cell lines upon CRISPR-mediated knockdown of MITF-M, as determined by Western and RT-qPCR (Dilshat et al, 2021).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
11818451 The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, KC, Marfatia, K, Purdom, GH, Luchin, A, Hume, DA, Ostrowski, MC

J Leukoc Biol 2002
Participants
Input
Output
Participates
as an event of
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
Cite Us!