MITF-M binds PXDN gene

Stable Identifier
R-HSA-9926491
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds PXDN gene
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MITF-M binds to the PXDN gene to repress its expression in melanoma cells. CRISPR- or siRNA-mediated MITF-M knockdown increases expression of PXDN, consistent with a repressive role for MITF-M at this locus. CUT-and-RUN and binding site motif analayses suggest that MITF-M binds directly to the PXDN gene region to repress its expression (Dilshat et al, 2021).
PXDN plays a role in extracellular matrix organization (ECM) and stability through its collagen crosslinking activity (Peterfi et al, 2009; Lee et al, 2020). By regulating the expression of PXDN and other ECM and focal adhesion-related genes, MITF-M impacts the balance of proliferative (higher MITF-M levels) versus quiescent or invasive properties of melanoma cells (lower MITF-M levels), as described by the "rheostat model" (Carreira et al, 2006; Dilshat et al, 2021; reviewed in Goding and Arnheiter, 2019; Rambow et al, 2019).
Literature References
PubMed ID Title Journal Year
17182868 Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Carreira, S, Goodall, J, Denat, L, Rodriguez, M, Nuciforo, P, Hoek, KS, Testori, A, Larue, L, Goding, CR

Genes Dev 2006
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
19590037 Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney

Péterfi, Z, Donkó, A, Orient, A, Sum, A, Prókai, A, Molnár, B, Veréb, Z, Rajnavölgyi, E, Kovács, KJ, Müller, V, Szabó, AJ, Geiszt, M

Am J Pathol 2009
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
32543734 Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly

Lee, SW, Kim, HK, Naidansuren, P, Ham, KA, Choi, HS, Ahn, HY, Kim, M, Kang, DH, Kang, SW, Joe, YA

FASEB J 2020
31575676 Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

Rambow, F, Marine, JC, Goding, CR

Genes Dev 2019
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Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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