MITF-M binds SOX2 gene

Stable Identifier
R-HSA-9926490
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds SOX2 gene
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SOX2 was identified as a putative MITF-M target gene in melanoma cells (Dilshat et al, 2021). CRISP-R or siRNA-mediated knockdown of MITF-M increases expression of SOX2, suggesting that MITF-M negatively regulates SOX2 expression (Dilshat et al, 2021). Motif analysis at the SOX2 locus identifies candidate MITF-M binding sites, and MITF-M has been shown to bind at SOX2 by CUT-and-RUN DNA binding analysis and by ChIP-seq (Dilshat et al, 2021; Laurette et al, 2015).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
Participants
Input
Output
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as an event of
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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