MITF-M binds CDH2 gene

Stable Identifier
R-HSA-9926474
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds CDH2 gene
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Expression of CDH2 (N-cadherin) is increased upon CRISPR- or siRNA-mediated knockdown of MITF-M in melanoma cells. Upregulation of CDH2 was confirmed by RT-qPCR and by Western blot analysis (Dishat et al, 2021). CUT-and-RUN and ChIP-seq analysis shows that MITF-M binds to the CDH2 gene region and cognate binding sites are identified by motif analysis (Dilshat et al, 2021; Laurette et al, 2015).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
Participants
Input
Output
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as an event of
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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