Reactome | Translation of NOTCH2NLB mRNA

Translation of NOTCH2NLB mRNA

Stable Identifier

R-HSA-9925719

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, nucleoplasm

ReviewStatus

5/5

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NOTCH2NLB mRNA is translated into NOTCH2NLB protein. The N-terminal portion of NOTCH2NLB corresponds to EGF repeats 1-6 of NOTCH2 (Fiddes et al. 2018). NOTCH2NLB does not contain regions that correspond to transmembrane and cytoplasmic domains of NOTCH2 (Fiddes et al. 2018). The C-terminus of ~20 amino acids is unique to NOTCH2NLs (Fiddes et al. 2018, Suzuki et al. 2018).

NOTCH2NLB is secreted (Fiddes et al. 2018).

The EGF repeats of NOTCH2NLB are critical for its role in cortical development (Suzuki et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
29856954	Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis Fiddes, IT, Lodewijk, GA, Mooring, M, Bosworth, CM, Ewing, AD, Mantalas, GL, Novak, AM, van den Bout, A, Bishara, A, Rosenkrantz, JL, Lorig-Roach, R, Field, AR, Haeussler, M, Russo, L, Bhaduri, A, Nowakowski, TJ, Pollen, AA, Dougherty, ML, Nuttle, X, Addor, MC, Zwolinski, S, Katzman, S, Kriegstein, A, Eichler, EE, Salama, SR, Jacobs, FMJ, Haussler, D	Cell	2018
29856955	Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation Suzuki, IK, Gacquer, D, Van Heurck, R, Kumar, D, Wojno, M, Bilheu, A, Herpoel, A, Lambert, N, Cheron, J, Polleux, F, Detours, V, Vanderhaeghen, P	Cell	2018