Ductal epithelial cells line the pancreatic ducts in a single layer, changing the shape as ducts increase in size from cuboidal, through low columnar, to high columnar epithelium (Liggitt and Dintzis, “Pancreas”, pp. 241-250). Ductal epithelial cells may have cilia or microvilli on their apical surface (Liggitt and Dintzis, “Pancreas”, pp. 241-250). Besides ductal epithelial cells, main pancreatic ducts sometimes include goblet cells (Liggitt and Dintzis, “Pancreas”, pp. 241-250).
Ductal epithelial cells develop from bipotent pancreatic trunk progenitor cells, which also give rise to endocrine progenitors and are derived from the primary multipotent pancreatic progenitor cells (reviewed in Shih et al. 2013, Jennings et al. 2015).
Shih, HP, Wang, A, Sander, M
Jennings, RE, Berry, AA, Strutt, JP, Gerrard, DT, Hanley, NA
Liggitt, D, Dintzis, SM
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