CDK5 phosphorylates PER2 on serine-396

Stable Identifier
R-HSA-9920673
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CDK5 phosphorylates PER2 on serine-396
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Cyclin-dependent kinase 5 (CDK5) phosphorylates PER2 on serine-396 (corresponding to serine-394 of mouse Per2) in the cytosol during the day (inferred from mouse homologs in Brenna et al. 2019). Phosphorylated PER2 interacts with CRY1 (inferred from mouse homologs) and CSNK1D or CSNK1E to form the PER:CRY:kinase complex which, after phosphorylation of PER and CRY proteins, enters the nucleus to negatively regulate the transactivation activity of BMAL1:CLOCK (reviewed in Takahashi et al. 2016).
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Catalyst Activity

protein serine/threonine kinase activity of CDK5 [cytosol]

Physical Entity
CDK5 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Cdk5 phosphorylates Per2 on serine-394 (Mus musculus)
Authored
May, B  (2024-08-20)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-03)
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