Reactome | DAG1(30-653) and DAG1(654-895) translocate to the Golgi

DAG1(30-653) and DAG1(654-895) translocate to the Golgi

Stable Identifier

R-HSA-9913337

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane, Golgi lumen, Golgi membrane

ReviewStatus

5/5

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DAG1(30-653) and DAG1(654-895) translocate to the Golgi

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Autolytic cleavage of DAG1 pre-protein yields alpha- and beta-DAG1 which remain non-covalently associated. Alpha-DAG1 is extensively N- and O-glycosylated in the ER and the Golgi, modifications that are required for its binding to laminin in the extracellular matrix Beta-DAG1 is also N-glysocsylated and remains assoicated with alpha-DAG1 at its cysteine-rich domain. In the Golgi, DAG1 alpha and beta-chains associate with other transmembrane components of the dystrophin-glycoprotein complex (DGC) such as the sarcoglycans and sarcospanin (Herzog et al, 2004; Akhavan et al, 2008; Oppizzi et al, 2008; Bozzi et al, 2009; reviewed in Bhat et al, 2018; Gawor and Prószyński, 2018).

Literature References

PubMed ID	Title	Journal	Year
15175026	Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface Herzog, C, Has, C, Franzke, CW, Echtermeyer, FG, Schlötzer-Schrehardt, U, Kröger, S, Gustafsson, E, Fässler, R, Bruckner-Tuderman, L	J Invest Dermatol	2004
19946898	Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site Bozzi, M, Inzitari, R, Sbardell, D, Monaco, S, Pavoni, E, Gioia, M, Marini, S, Morlacchi, S, Sciandra, F, Castagnola, M, Giardina, B, Brancaccio, A, Coletta, M	IUBMB Life	2009
28464259	ABC of multifaceted dystrophin glycoprotein complex (DGC) Bhat, HF, Mir, SS, Dar, KB, Bhat, ZF, Shah, RA, Ganai, NA	J Cell Physiol	2018
18764929	Nuclear translocation of beta-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins Oppizzi, ML, Akhavan, A, Singh, M, Fata, JE, Muschler, JL	Traffic	2008
29068540	The molecular cross talk of the dystrophin-glycoprotein complex Gawor, M, Prószyński, TJ	Ann N Y Acad Sci	2018
17905726	SEA domain proteolysis determines the functional composition of dystroglycan Akhavan, A, Crivelli, SN, Singh, M, Lingappa, VR, Muschler, JL	FASEB J	2008