Reactome | SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD

SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD

Stable Identifier

R-HSA-9913330

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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After formation of the beta-delta core, gamma-sarcoglycan (SGCG) is recruited through interaction with SGCD. Following this, the more loosely associated alpha subunit SGCA is recruited (Shi et al, 2004; reviewed in Tarakci and Berger, 2016; Bhat et al, 2018).
In smooth muscle tissue, SGCD and SGCA are replaced by SGCZ and SGCE, respectively (Wheeler et al, 2002; Ettinger et al, 1997; reviewed in Bhat et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
9405466	epsilon-Sarcoglycan, a broadly expressed homologue of the gene mutated in limb-girdle muscular dystrophy 2D Ettinger, AJ, Feng, G, Sanes, JR	J Biol Chem	1997
14981741	Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan Shi, W, Chen, Z, Schottenfeld, J, Stahl, RC, Kunkel, LM, Chan, YM	Muscle Nerve	2004
28464259	ABC of multifaceted dystrophin glycoprotein complex (DGC) Bhat, HF, Mir, SS, Dar, KB, Bhat, ZF, Shah, RA, Ganai, NA	J Cell Physiol	2018
26709803	The sarcoglycan complex in skeletal muscle Tarakci, H, Berger, J	Front Biosci (Landmark Ed)	2016
12189167	Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy Wheeler, MT, Zarnegar, S, McNally, EM	Hum Mol Genet	2002