RMTases methylate 16S ribosomal RNA

Stable Identifier
R-HSA-9911509
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Klebsiella pneumoniae
Compartment
cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RMTases methylate 16S ribosomal RNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Several 16S rRNA (guanine(1405)-N(7))-methyltransferase (16S RMTase) genes have been found in Klebsiella pneumoniae, often colocated with NDM-type carbapenemase genes. The enzymes methylate the 16S rRNA part of the prokaryotic small (30S) ribosomal subunit at the 1405-guanosine position, using up one S-adenosylmethionine (SAM) molecule, thereby preventing the binding of 4,6-disubstituted aminoglycosides like gentamicin. At least eight different 16S RMTase genes have been isolated from K.pneumoniae infecting patients worldwide (Bueno et al., 2013; Galimand et al., 2005; Galimand et al. 2012; Hu et al., 2014; Poirel et al., 2011; Tada et al., 2013; Wachino et al., 2012; reviewed in Doi et al., 2016).
Literature References
PubMed ID Title Journal Year
23478957 Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma

O'Hara, JA, McGann, P, Snesrud, EC, Clifford, RJ, Waterman, PE, Lesho, EP, Doi, Y

Antimicrob Agents Chemother 2013
22547620 RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family

Galimand, M, Courvalin, P, Lambert, T

Antimicrob. Agents Chemother. 2012
27208771 Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases

Doi, Y, Wachino, JI, Arakawa, Y

Infect Dis Clin North Am 2016
23459483 Coproduction of 16S rRNA methyltransferase RmtD or RmtG with KPC-2 and CTX-M group extended-spectrum β-lactamases in Klebsiella pneumoniae

Bueno, MF, Francisco, GR, O'Hara, JA, de Oliveira Garcia, D, Doi, Y

Antimicrob Agents Chemother 2013
22673098 Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update

Wachino, J, Arakawa, Y

Drug Resist Updat 2012
24841274 Klebsiella pneumoniae sequence type 11 isolate producing RmtG 16S rRNA methyltransferase from a patient in Miami, Florida

Hu, F, Munoz-Price, LS, DePascale, D, Rivera, JI, Doi, Y

Antimicrob Agents Chemother 2014
23978353 Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal

Tada, T, Miyoshi-Akiyama, T, Dahal, RK, Mishra, SK, Ohara, H, Shimada, K, Kirikae, T, Pokhrel, BM

Int J Antimicrob Agents 2013
21628303 Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland

Poirel, L, Schrenzel, J, Cherkaoui, A, Bernabeu, S, Renzi, G, Nordmann, P

J Antimicrob Chemother 2011
15980373 Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548

Galimand, M, Sabtcheva, S, Courvalin, P, Lambert, T

Antimicrob Agents Chemother 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

rRNA methyltransferase activity of 16S RMTases [cytosol]

Physical Entity
16S RMTases [cytosol] (Klebsiella pneumoniae)
Activity
rRNA methyltransferase activity (GO:0008649)
Disease
Cross References
RHEA
Mondo
Authored
Stephan, R  (2019-02-19)
Created
Stephan, R  (2024-06-01)
Cite Us!