Formation of the PA28gamma homoheptamer

Stable Identifier
R-HSA-9908723
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of the PA28gamma homoheptamer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PSME3 (PA28gamma) forms a homoheptamer (PA28gamma homoheptamer) that serves as an alternative regulatory particle (RP) of the 20S core particle (20S CP) of the proteasome. The structure and stoichiometry of the human PA28gamma homoheptamer was determined from the density map of PA28 proteasomes isolated from human embryonic kidney cell line HEK293T (Zhao et al. 2022)
Literature References
PubMed ID Title Journal Year
35858375 Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins

Huang, B, Makhija, S, Zhang, H, Zhao, J, Cheng, Y, Muralidharan, M, Wang, Y, Zhou, C

Proc Natl Acad Sci U S A 2022
Participants
Input
Output
Participates
as an event of
Orthologous Events
Formation of the PA28gamma homoheptamer (Caenorhabditis elegans)
Formation of the PA28gamma homoheptamer (Danio rerio)
Formation of the PA28gamma homoheptamer (Dictyostelium discoideum)
Formation of the PA28gamma homoheptamer (Drosophila melanogaster)
Formation of the PA28gamma homoheptamer (Gallus gallus)
Formation of the PA28gamma homoheptamer (Mus musculus)
Formation of the PA28gamma homoheptamer (Plasmodium falciparum)
Formation of the PA28gamma homoheptamer (Sus scrofa)
Formation of the PA28gamma homoheptamer (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-22)
Cite Us!