Maturation of the 20S immunoproteasome core particle

Stable Identifier
R-HSA-9908105
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Maturation of the 20S immunoproteasome core particle
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Based on the analogy with the canonical 20S core particle (20S CP), it is assumed that, upon dimerization of two half-immunoproteasomes to form the preholoimmunoproteasome, the active site–bearing beta-subunits, PSMB9 (beta-1i), PSMB10 (beta-2i), and PSMB8 (beta-5i), undergo autocatalytic cleavage of their propeptides, generating the mature catalytic sites and completing the immunoproteasome 20S core particle (20S iCP) assembly (reviewed in Tomko and Hochstrasser 2013).
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Output
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as an event of
Catalyst Activity

endopeptidase activity of Preholoimmunoproteasome [cytosol]

Physical Entity
Preholoimmunoproteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Maturation of the canonical 20S core particle (Homo sapiens)
Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-18)
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