Reactome | POMP binds the 20S core particle outer ring

POMP binds the 20S core particle outer ring

Stable Identifier

R-HSA-9908069

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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POMP binds the 20S core particle outer ring

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POMP (UMP1), proteasome maturation protein which may function as a homotetramer (Hoefer et al. 2006), binds the formed outer ring (Hirano et al. 2006). Binding of POMP to the outer ring is mutually exclusive with binding of PSMG3:PSMG4 dimer to the outer ring (Hirano et al. 2006), although a transient interaction between PSMG3:PSMG4 and POMP was detected by the analysis of 20S core particle intermediates (Adolf et al. 2024). Dissociation of PSMG3 from the outer ring during formation of half-proteasomes was reported in human cells (Hirano et al. 2006) and shown to happen after the incorporation of beta-3 (PSMB3) (Hirano et al. 2008). POMP initiates the assembly of the inner ring. Beta subunits (PSMBs) of the inner ring assemble onto the inner surface of outer ring. POMP may help prevent the premature dimerization of precursors containing incomplete sets of beta subunits (reviewed in Tomko and Hochstrasser 2013).

Literature References

PubMed ID	Title	Journal	Year
17189198	Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes Hirano, Y, Hayashi, H, Iemura, S, Hendil, KB, Niwa, S, Kishimoto, T, Kasahara, M, Natsume, T, Tanaka, K, Murata, S	Mol Cell	2006
38600324	Visualizing chaperone-mediated multistep assembly of the human 20S proteasome Adolf, F, Du, J, Goodall, EA, Walsh, RM, Rawson, S, von Gronau, S, Harper, JW, Hanna, J, Schulman, BA	Nat Struct Mol Biol	2024