Formation of the lid particle 2 (LP2)

Stable Identifier
R-HSA-9908014
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Formation of the lid particle 2 (LP2)
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Two subcomplexes of the proteasome 19S regulatory particle (19S RP) lid, Module1 and lid particle 3 (LP3), associate to form the lid particle 2 (LP2) (reviewed in Tomko and Hochstrasser 2013). Existence of the lid subcomplex corresponding to LP2 was confirmed in human embryonic kidney cell line HEK293T, where it was shown that PSMD11 (Rpn6) of the LP3 subcomplex plays a crucial role in connecting Module 1 and LP3 into LP2, through directly interacting with the Module 1 subunit PSMD6 (Rpn7) (Bai et al. 2019).
Literature References
PubMed ID Title Journal Year
31159305 In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals

Bai, M, Zhao, X, Sahara, K, Ohte, Y, Hirano, Y, Kaneko, T, Yashiroda, H, Murata, S

Biomolecules 2019
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Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-18)
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