Reactome | Formation of the inner ring of the 20S thymoproteasome core particle

Formation of the inner ring of the 20S thymoproteasome core particle

Stable Identifier

R-HSA-9907928

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Formation of the inner ring of the 20S thymoproteasome core particle

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In the thymoproteasomes, expressed exclusively in cortical thymic epithelial cells in the thymus, the 20S core particle (20S tCP) inner ring proteolytic subunits, PSMB6 (beta-1), PSBM7 (beta-2), and PSMB5 (beta-5), are replaced with PSMB9 (beta-1i), PSMB10 (beta-2i) and PSMB11 (beta-5t) , respectively (Murata et al. 2007: endogenous mouse proteins; Bai et al. 2014: recombinant human proteins). The order of incorporation of beta subunits in thymoproteasomes likely differs from the order of incorporation in the canonical 20S CPs (Bai et al. 2014). Thymoproteasomes appear to increase the repertoire of self peptides for positive selection during T cell development in the thymus (reviewed in Tomko and Hochstrasser 2013).

Literature References

PubMed ID	Title	Journal	Year
25033340	Assembly mechanisms of specialized core particles of the proteasome Zhao, X, Murata, S, Hirano, Y, Sahara, K, Bai, M, Ohte, Y, Yashiroda, H, Kaneko, T	Biomolecules	2014
17540904	Regulation of CD8+ T cell development by thymus-specific proteasomes Murata, S, Kishimoto, T, Tanaka, K, Niwa, S, Hayashi, H, Sasaki, K, Takahama, Y	Science	2007