Formation of the inner ring of the 20S immunoproteasome core particle

Stable Identifier
R-HSA-9907925
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of the inner ring of the 20S immunoproteasome core particle
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the immunoproteasomes, the 20S core particle (20S iCP) inner ring subunits with proteolytic activity, PSMB6 (beta-1), PSMB7 (beta-2), and PSMB5 (beta-5), are substituted with PSMB9 (beta-1i), PSMB10 (beta-2i), and PSMB8 (beta-5i), respectively (Bai et al. 2014). The order of incorporation of beta subunits in immunoproteasomes likely differs from the order of incorporation in the canonical 20S CPs (Bai et al. 2014). The immunoproteasome generates substrate cleavage patterns that enhance loading of peptides onto the class I major histocompatibility complex (MHC I) for immune presentation to killer T cells (reviewed in Tomko and Hochstrasser 2013).
Literature References
PubMed ID Title Journal Year
25033340 Assembly mechanisms of specialized core particles of the proteasome

Bai, M, Zhao, X, Sahara, K, Ohte, Y, Hirano, Y, Kaneko, T, Yashiroda, H, Murata, S

Biomolecules 2014
Participants
Input
Output
Participates
as an event of
Orthologous Events
Formation of the inner ring of the 20S immunoproteasome core particle (Bos taurus)
Formation of the inner ring of the 20S immunoproteasome core particle (Dictyostelium discoideum)
Formation of the inner ring of the 20S immunoproteasome core particle (Drosophila melanogaster)
Formation of the inner ring of the 20S immunoproteasome core particle (Mus musculus)
Formation of the inner ring of the 20S immunoproteasome core particle (Rattus norvegicus)
Formation of the inner ring of the 20S immunoproteasome core particle (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2024-04-22)
Created
Orlic-Milacic, M  (2024-04-18)
Cite Us!