IRF4 binds the TYR promoter

Stable Identifier
R-HSA-9907145
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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IRF4 binds the TYR promoter
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IRF4 binds to elements in the promoter of the TYR gene to promote its expression, as assesed by reporter gene and ChIP in melanocytes and melanoma cell lines (Praetorious et al, 2013). Consistent with this, knockdown of IRF4 decreases TYR expression in 501mel cells. IRF4-dependent TYR expression depends on cooperation with MITF-M, as demonstrated by co-transfection assays in HEK293 cells (Praetorius et al, 2013).
Literature References
PubMed ID Title Journal Year
24267888 A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway

Bergsteinsdóttir, K, Petit, V, Ogmundsdóttir, MH, Stacey, SN, Robinson, KC, Davis, SR, Stefansson, K, Larue, L, Smith, AG, Magnusdottir, E, Cornell, R, Helgason, AS, Adams, DR, Merlino, G, Grill, C, Mishra, PJ, Praetorius, C, Meltzer, PS, Sturm, RA, Mccallion, AS, Emre, NC, Fisher, DE, Guo, T, Metcalf, AM, Kim, RS, Sigurdsson, MI, Sobhiafshar, U, Zaidi, MR, Gorkin, DU, Van Otterloo, E, Pavan, WJ, Loftus, SK, Steingrímsson, E

Cell 2013
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Authored
Rothfels, K  (2024-03-01)
Reviewed
de la Serna, IL  (2024-05-21)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-04-04)
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