Interaction of PCBP2 with MAVS

Stable Identifier
R-HSA-990528
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of PCBP2 with MAVS
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Poly(rC) binding protein 2 (PCB2), is one of the negative regulators of RIG-I/MDA5 signaling. It interacts with MAVS/IPS-1 and mediates its ubiquitin/proteasomal degradation by recruiting E3 ligase AIP4/ITCHY.

Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

You, F, Sun, H, Zhou, X, Sun, W, Liang, S, Zhai, Z, Jiang, Z

Nat Immunol 2009
Participants
Input
Output
Participant Of
hasEvent
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-11-03)