Interaction of PCBP2 with MAVS

Stable Identifier
R-HSA-990528
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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Interaction of PCBP2 with MAVS
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Poly(rC) binding protein 2 (PCB2), is one of the negative regulators of RIG-I/MDA5 signaling. It interacts with MAVS/IPS-1 and mediates its ubiquitin/proteasomal degradation by recruiting E3 ligase AIP4/ITCHY.

Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

You, F, Sun, H, Zhou, X, Sun, W, Liang, S, Zhai, Z, Jiang, Z

Nat Immunol 2009
Participants
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Participant Of
hasEvent
Cross References
Target Pathogen
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-11-03)
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