Kinesin-13 is a dimer

Stable Identifier
R-HSA-990489
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Kinesin-13 is a dimer
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Kinesin-13 proteins are homodimeric with the kinesin motor in the middle of the amino acid sequence. They induce microtubule depolymerization by disassembling tubulin subunits from the polymer end (Desai et al. 1999).
Literature References
PubMed ID Title Journal Year
7822426 Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis

Wordeman, L, Mitchison, TJ

J Cell Biol 1995
17538014 The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells

Manning, AL, Ganem, NJ, Bakhoum, SF, Wagenbach, M, Wordeman, L, Compton, DA

Mol Biol Cell 2007
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Orthologous Events
Kinesin-13 is a dimer (Bos taurus)
Kinesin-13 is a dimer (Caenorhabditis elegans)
Kinesin-13 is a dimer (Canis familiaris)
Kinesin-13 is a dimer (Danio rerio)
Kinesin-13 is a dimer (Drosophila melanogaster)
Kinesin-13 is a dimer (Gallus gallus)
Kinesin-13 is a dimer (Mus musculus)
Kinesin-13 is a dimer (Rattus norvegicus)
Kinesin-13 is a dimer (Sus scrofa)
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2010-11-03)
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