Intermediate I binds second heme, UQCRB, UQCRQ

Stable Identifier
R-HSA-9866104
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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Intermediate I binds second heme, UQCRB, UQCRQ
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Binding of the second heme to the MT-CYB subunit of intermediate I of the cytochrome b assembly process triggers the additional insertion of the UQCRB and UQCRQ subunits, subsequently releasing the chaperone complex UQCC1:UQCC2:UQCC5:UQCC6 (Guo et al., 2017; reviewed in Ndi et al., 2018; Zara et al., 2022). This assembly step is inferred from its equivalent in yeast.
Literature References
PubMed ID Title Journal Year
36142449 Assembly of the Multi-Subunit Cytochrome bc1 Complex in the Yeast Saccharomyces cerevisiae

Zara, V, Ferramosca, A, De Blasi, G

Int J Mol Sci 2022
28844695 Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2

Guo, R, Zong, S, Yang, M, Gu, J, Wu, M

Cell 2017
29733856 Biogenesis of the bc1 Complex of the Mitochondrial Respiratory Chain

Marin-Buera, L, Ott, M, Salvatori, R, Ndi, M, Singh, AP

J Mol Biol 2018
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
mitochondrial respiratory chain complex III assembly (0034551)
Inferred From
CYTB binds second heme, QCR7, QCR8 (Saccharomyces cerevisiae)
Authored
Stephan, R  (2024-03-22)
Reviewed
Hill, DP  (2024-05-16)
Created
Stephan, R  (2024-03-22)
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