Reactome | Metallochaperone inserts Cu2+ into MT-CO1

Metallochaperone inserts Cu2+ into MT-CO1

Stable Identifier

R-HSA-9865449

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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Metallochaperone inserts Cu2+ into MT-CO1

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A metallochaperone complex consisting of nine subunits (COA3, COA5, COX10, dimeric COX11, COX15, COX16, COX19, SCO1, SCO2) carries a copper cation from the outer side of the inner mitochondrial membrane, where it was delivered by the copper chaperone COX17, to the pre-assembled Complex IV on the inner side of the membrane, where it inserts the cation into the MT-CO1 subunit. This copper ion is frequently called CuB (Leary et al., 2013; Bode et al., 2015; Nývltová et al., 2022; reviewed in Ruiz et al., 2021).

Literature References

PubMed ID	Title	Journal	Year
25926683	Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase Jung, M, Bode, M, Zimmermann, R, Schroda, M, Bohnert, M, Woellhaf, MW, van der Laan, M, Herrmann, JM, Sommer, F	Mol Biol Cell	2015
34504870	Role of Copper on Mitochondrial Function and Metabolism Ruiz, LM, Elorza, AA, Libedinsky, A	Front Mol Biosci	2021
23345593	COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux de Coo, R, de Krijger, R, Shoubridge, EA, Winge, DR, Verdijk, RM, Nishimura, T, Cobine, PA, Leary, SC, Tarnopolsky, MA	Mol Biol Cell	2013
35750769	Coordination of metal center biogenesis in human cytochrome c oxidase Dietz, JV, Nývltová, E, Seravalli, J, Barrientos, A, Khalimonchuk, O	Nat Commun	2022