Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL

Stable Identifier
R-HSA-9865350
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL
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Nascent MT-CO1 binds to Mitochondrial Translation Regulation and Assembly Complex (MITRAC), consisting of the subunits CMC1 (C3orf68), COX14 (C12orf62), COA1 (C7orf44, MITRAC15), COA3 (MITRAC12) (Mick et al., 2012; Bourens & Barrientos, 2017) SMIM20 (C4orf52, MITRAC7), and SURF1 (Zhu et al., 1998; Dennerlein et al., 2015). Also, during the folding process, MT-CO1 incorporates an Mg2+ ion and one molecule of each phosphatidylethanolamine (PE) and cardiolipin (CL). The existence of these cofactors is derived from the Cryo-EM structure of Complex IV (PDB 5Z62; Zong et al., 2018).
Literature References
PubMed ID Title Journal Year
9843204 SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome

Fu, K, Brown, GK, Zhu, Z, De Bie, I, Newbold, RF, Cuthbert, AP, Yao, J, Chevrette, M, Shoubridge, EA, Brown, RM, Wang, J, Johns, T, Macmillan, C

Nat Genet 1998
28082314 A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis

Bourens, M, Barrientos, A

EMBO Rep 2017
23260140 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation

Lorenzi, I, Wiese, H, Reinhold, R, Warscheid, B, Sasarman, F, Rehling, P, Shoubridge, EA, Weraarpachai, W, Mick, DU, Dennerlein, S, Pacheu-Grau, D

Cell 2012
26321642 MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly

Deckers, M, Hellwig, C, Warscheid, B, Jakobs, S, Bareth, B, Rehling, P, Jans, D, Oeljeklaus, S, Dennerlein, S

Cell Rep 2015
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
chaperone-mediated protein folding (0061077)
Orthologous Events
Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Bos taurus)
Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Drosophila melanogaster)
Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Mus musculus)
Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Sus scrofa)
Authored
Stephan, R  (2024-03-10)
Reviewed
Hill, DP  (2024-05-16)
Created
Stephan, R  (2024-03-10)
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