Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
Stable Identifier
R-HSA-9864456
Type
Complex
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
CO binds to Cytochrome c oxidase (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex IV assembly (Homo sapiens)
MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Homo sapiens)
holo-MT-CO1,2 complex [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
holo-MT-CO1,2 complex [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
30030519
Structure of the intact 14-subunit human cytochrome c oxidase
Zong, S
,
Wu, M
,
Gu, J
,
Liu, T
,
Guo, R
,
Yang, M
Cell Res
2018
Participants
components
cardiolipin [mitochondrial inner membrane]
Cu2+ [mitochondrial inner membrane]
heme A [mitochondrial inner membrane]
heme a3 [mitochondrial inner membrane]
Mg2+ [mitochondrial inner membrane]
nascent MT-CO1 [mitochondrial inner membrane]
(Homo sapiens)
PE [mitochondrial inner membrane]
Participates
as a component of
holo-MT-CO1,2 complex [mitochondrial inner membrane] (Homo sapiens)
COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
Inferred To
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Bos taurus)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Canis familiaris)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Danio rerio)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Drosophila melanogaster)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Gallus gallus)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Mus musculus)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Rattus norvegicus)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Sus scrofa)
MT-CO1:heme a:heme a3:Cu2+:Mg2+:PE:CL [mitochondrial inner membrane]
(Xenopus tropicalis)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text