NEK1 phosphorylates ME1

Stable Identifier
R-HSA-9861642
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Serine/threonine-protein kinase NEK1 (aka NimA-related protein kinase 1) phosphorylates cytosolic malic enzyme 1 (ME1) at Ser-336, inhibiting its catalytic activity (Zhu et al., 2020). Mutations in NEK1 can lead to a form of amyotrophic lateral sclerosis (ALS24, MIM:617892; Mann et al., 2023; reviewed by Yao et al., 2021), as well as a form of short-rib thoracic dysplasia (SRT6, MIM:263520; El Hokayem et al., 2012).
Literature References
PubMed ID Title Journal Year
22499340 NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases

Munnich, A, Cordier, MP, Gonzales, M, El Hokayem, J, Le Merrer, M, Levy-Mozziconacci, A, Delezoide, AL, Roume, J, Martinovic, J, Loget, P, Johnson, D, Couvé, A, Mortier, GR, Scarano, G, Bouvier, R, Martin-Coignard, D, Cavalcanti, DP, Collins, FA, Cormier-Daire, V, Perez, MJ, Baujat, G, Aziza, J, Huber, C

J Med Genet 2012
33462636 NEK1 mutations and the risk of amyotrophic lateral sclerosis (ALS): a meta-analysis

Zhao, F, He, X, Zhou, C, Yao, L, Cui, B

Neurol Sci 2021
37585529 Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import

Baron, DM, Kaspi, E, Ball, HE, Lubinski, K, Tellez, L, Mann, JR, Mawrie, D, Alessandrini, F, Pandey, UB, Landers, JE, Papakis, V, Kiskinis, E, McKenna, ED, Mayers, R, Anderson, EN

Sci Adv 2023
31735643 Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

Lin, X, Li, Y, Zhu, Y, Gu, L, Prochownik, EV, Fan, C, Zhao, Q, Zhou, F, Lu, B, Cui, K, Liu, C

Mol Cell 2020
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of NEK1:Mg2+ [cytosol]

Orthologous Events
Cross References
RHEA
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