Reactome | NEK1 [cytosol]

NEK1 [cytosol]

Stable Identifier

R-HSA-9861542

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - Regulation of pyruvate metabolism (Homo sapiens)
      - NEK1 phosphorylates ME1 (Homo sapiens)
        
        NEK1:Mg2+ [cytosol] (Homo sapiens)
        
        NEK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PY6 NEK1

Gene Names

NEK1, KIAA1901

Chain

chain:1-1258

Reference Genes

BioGPS Gene:4750 NEK1

COSMIC (genes):NEK1 NEK1

CTD Gene:4750 NEK1

dbSNP Gene:4750 NEK1

ENSEMBL:ENSG00000137601 NEK1

HGNC:7744 NEK1

KEGG:hsa:4750 NEK1

Monarch:4750 NEK1

NCBI Gene:4750 NEK1

OMIM:604588 NEK1

UCSC:Q96PY6 NEK1

Reference Transcript

Other Identifiers

11729396_a_at

11751959_a_at

11757406_s_at

1285_at

16981364

211086_PM_x_at

211086_x_at

213328_PM_at

213328_at

213331_PM_s_at

213331_s_at

2793220

2793222

2793223

2793227

2793228

2793229

2793230

2793231

2793236

2793237

2793238

2793239

2793240

2793241

2793242

2793243

2793244

2793246

2793247

2793248

2793249

2793250

2793255

2793256

2793257

2793258

2793259

2793260

2793261

2793262

2793263

2793264

2793266

2793267

2793268

2793269

2793276

2793277

2793278

2793279

2793281

2793282

2793284

2793287

2793288

2793289

2793291

2793292

2793293

2793294

2793295

36047_at

4079068

4750

8103646

A_23_P124427

A_24_P50882

A_32_P68050

GE56303

GO:0000242

GO:0003824

GO:0004672

GO:0004674

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0016301

GO:0016740

GO:0030030

GO:0034451

GO:0043226

GO:0044782

GO:0046872

GO:0051301

GO:0060271

GO:0071889

GO:0106310

GO:0140096

HMNXSV003012463

Hs.48332.0.S1_3p_at

Hs.48332.0.S2_3p_a_at

ILMN_2162234

PH_hs_0024983

TC04001725.hg

g405740_3p_at

Participates

as a component of

NEK1:Mg2+ [cytosol] (Homo sapiens)

Inferred To

A0A287AWJ2 [cytosol] (Sus scrofa)

A0A0G2K5C7 [cytosol] (Rattus norvegicus)

A0A1D5P1N0 [cytosol] (Gallus gallus)

E1BBM3 [cytosol] (Bos taurus)

A0A8I3Q006 [cytosol] (Canis familiaris)

P51954 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_001186329.1, NP_001186327.1, NP_036356.1, NP_001186328.1, NP_001186326.1, XP_011530305.1, XP_011530306.1

Guide to Pharmacology - Targets

2114

OpenTargets

ENSG00000137601

ENSEMBL

ENSG00000137601, ENSP00000424757, ENST00000512193, ENSP00000423332, ENST00000439128, ENSP00000427653, ENST00000510533, ENSP00000408020, ENST00000511633, ENST00000507142, ENSP00000424938

ZINC - Substances

NEK1_HUMAN

ZINC - Biogenic

NEK1_HUMAN

ZINC target

Q96PY6

PRO

Q96PY6

PDB

4B9D, 4APC

ZINC - Investigational

NEK1_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000137601-NEK1

GeneCards

NEK1

Pharos - Targets

Q96PY6

Orphanet

NEK1

ZINC - Predictions - Purchasable

NEK1_HUMAN

HMDB Protein

HMDBP01174

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	4
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.508	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.483	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3