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p-Y1063,Y1230-FLT4 [plasma membrane]
Stable Identifier
R-HSA-9860553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Vascular endothelial growth factor receptor 3, VGFR3_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y1063,Y1230-FLT4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35916 FLT4
Gene Names
FLT4, VEGFR3
Chain
signal peptide:1-24, chain:25-1363
Reference Genes
BioGPS Gene:2324 FLT4
COSMIC (genes):FLT4 FLT4
CTD Gene:2324 FLT4
dbSNP Gene:2324 FLT4
ENSEMBL:ENSG00000037280 FLT4
HGNC:3767 FLT4
KEGG:hsa:2324 FLT4
Monarch:2324 FLT4
NCBI Gene:2324 FLT4
OMIM:136352 FLT4
UCSC:P35916 FLT4
Reference Transcript
RefSeq:NM_182925.5 FLT4
RefSeq:NM_002020.5 FLT4
Other Identifiers
11726169_at
11726170_at
11740292_a_at
11750407_a_at
11753432_a_at
11753542_a_at
17003958
210316_PM_at
210316_at
229902_PM_at
229902_at
2324
234379_PM_at
234379_at
2890757
2890758
2890759
2890760
2890761
2890762
2890763
2890764
2890765
2890766
2890767
2890768
2890769
2890770
2890775
2890776
2890777
2890778
2890779
2890780
2890781
2890782
2890783
2890784
2890785
2890786
2890787
2890788
2890789
2890790
2890791
2890792
2890793
2890794
2890795
2890796
2890797
2890798
2890799
2890800
2890808
2890809
403_s_at
55409_at
8116445
A_23_P213394
A_23_P356070
A_24_P926979
A_33_P3409269
GE81101
GE85623
GO:0001525
GO:0001934
GO:0001938
GO:0001944
GO:0001945
GO:0001946
GO:0002040
GO:0003016
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005004
GO:0005005
GO:0005006
GO:0005007
GO:0005008
GO:0005009
GO:0005010
GO:0005011
GO:0005018
GO:0005019
GO:0005020
GO:0005021
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005886
GO:0006468
GO:0007169
GO:0007173
GO:0007585
GO:0008284
GO:0008286
GO:0008288
GO:0008543
GO:0010575
GO:0010595
GO:0016301
GO:0016477
GO:0016740
GO:0018108
GO:0019838
GO:0019903
GO:0030335
GO:0031547
GO:0035790
GO:0035791
GO:0035924
GO:0036323
GO:0036332
GO:0038062
GO:0038063
GO:0038084
GO:0038109
GO:0038145
GO:0042127
GO:0042803
GO:0043066
GO:0043226
GO:0043235
GO:0043410
GO:0046330
GO:0046777
GO:0046872
GO:0048009
GO:0048010
GO:0048012
GO:0048013
GO:0048286
GO:0048514
GO:0048856
GO:0048870
GO:0060089
GO:0060175
GO:0060312
GO:0070374
GO:0140096
HMNXSV003009332
HMNXSV003026463
Hs.248032.0.S1_3p_at
Hs.8941.0.A1_3p_at
ILMN_1651296
ILMN_1794741
ILMN_2390427
PH_hs_0033241
TC05002148.hg
TC05003386.hg
X69878_at
g1150990_3p_at
Participates
as a component of
p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
FLT4 [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 1230
Coordinate
1230
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1063
Coordinate
1063
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002011.2
,
NP_891555.2
ZINC - World Drugs
VGFR3_HUMAN
Guide to Pharmacology - Targets
1814
ENSEMBL
ENSG00000037280
,
ENST00000393347
,
ENSP00000377016
,
ENST00000261937
,
ENSP00000261937
OpenTargets
ENSG00000037280
ZINC - FDA approved
VGFR3_HUMAN
ZINC - Substances
VGFR3_HUMAN
ZINC - Biogenic
VGFR3_HUMAN
ZINC target
P35916
PRO
P35916
GlyGen
P35916
PDB
4BSK
,
4BSJ
ZINC - Investigational
VGFR3_HUMAN
ZINC - Metabolites
VGFR3_HUMAN
IntEnz
2.7.10.1
GeneCards
FLT4
HPA
ENSG00000037280-FLT4
Pharos - Targets
P35916
Orphanet
FLT4
ZINC - Predictions - Purchasable
VGFR3_HUMAN
HMDB Protein
HMDBP01160
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.702
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.641
3
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.527
2
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