MITF-M dimer binds the CCND1 gene

Stable Identifier
R-HSA-9858650
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the CCND1 gene
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Expression of the G1/S cyclin CCND1 is activated by MITF, and MITF binds to an E-box element in its promoter as assessed by ChIP. Consistent with this, expression of a CCND1 reporter is abrogated upon siRNA-mediated knockdown of MITF (Strub et al, 2011). CCND1 has additionally been identified as a direct target of beta-catenin-mediated upregulation in melanoma cells, and this activity appears to be repressible by a complex of HINT1, SIN3A and HDAC1 (Genovese et al, 2013).
MITF- and beta-catenin-dependent CCND1 expression in melanoma cells contributes to the proliferative phenotype of cells expressing intermediate levels of MITF (reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
22647378 The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells

Sioletic, S, Sgambato, A, Cittadini, A, Rettino, A, Ghosh, P, Genovese, G, Li, H

Cell Cycle 2012
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Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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