TCF/LEF:CTNNB1 binds the CCND1 gene

Stable Identifier
R-HSA-9858646
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TCF/LEF:CTNNB1 binds the CCND1 gene
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CCND1 expression in melanoma cells depends in part on the binding of CTNNB1 to a cognate site in the CCND1 promoter, as assessed by ChIP and reporter gene assay. Consistent with this, mutation of the TCF/LEF binding site abrogates expression of the CCND1 reporter CTNNB1-dependent activation of CCND1 expression can be inhibited by recruitment of the HINT1 repressor along with co-repressors SIN3A and HDAC1 (Genovese et al, 2013).
Literature References
PubMed ID Title Journal Year
22647378 The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells

Sioletic, S, Sgambato, A, Cittadini, A, Rettino, A, Ghosh, P, Genovese, G, Li, H

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1 [nucleoplasm]
SIN3A [nucleoplasm]
HINT1 [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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