MITF-M dimer binds the PLK1 gene

Stable Identifier
R-HSA-9858639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the PLK1 gene
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By ChIP in melanoma cells, MITF binds to an E-box at position -133 to -122 in the PLK1 (Polo-like kinase 1)promoter to drive expression. siRNA depletion of MITF in these cells reduces PLK1 protein levels. PLK1 was identified as one of a large number of genes involved in mitotic progression that are directly or indirectly regulated by MITF, contributing to the proliferative capacity of these cells (Strub et al, 2011; reviewed in Goding and Arnheiter, 2019). Inhibition of PLK1 in human melanomas reduces colonogenic survival, promotes multiple mitotic errors, G2/M cell-cycle arrest and apoptosis (Schmidt et al, 2009).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
19554017 Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells

Schmit, TL, Zhong, W, Setaluri, V, Spiegelman, VS, Ahmad, N

J Invest Dermatol 2009
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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