MITF-M-dependent PLK1 expression

Stable Identifier
R-HSA-9858636
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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MITF-M-dependent PLK1 expression
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PLK1 has been identified as a direct target of MITF activation in melanoma cells by ChIP. Consistent with this, siRNA-mediated depletion of MITF causes a reduction in PLK1 protein and a concomitant increase in cells displaying mitotic aberrations in spindle and chromosome organization (Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:PLK1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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